Fetal Hydantoin Dilantin Syndrome

Dilantin® is the brand name of the prescription drug phenytoin sodium in the United States of America, commonly used in the treatment of epilepsy.

The entire collection of defects / birth abnormalities caused by the drug's teratogenicity is called Fetal Dilantin Syndrome.

It may also be referred to as congenital hydantoin syndrome,[1] Fetal Hydantoin Syndrome, Dilantin Embryopathy, or Phenytoin Embryopathy.

Association with EPHX1 has been suggested.[2]

Prevalence and Symptoms:

About one third (1/3) of children / infants whose mothers are taking Dilantin during pregnancy typically have children / infants / babies who have intrauterine growth restriction with microcephaly and develop minor dysmorphic craniofacial features and limb defects including hypoplastic nails and distal phalanges (birth defects).

A smaller number of people will apparently have growth problems & developmental delay / retardation, or mental retardation. Rare side effects include methemoglobinemia.

Heart defects and cleft lip[3] may also be featured as symptoms.

If you or a loved one have been affected by Dilantin or another drug and have a potential claim for birth defects related to any drug, please contact us immediately. We will provide you with a free initial case evaluation. Failure to act quickly may cause you to lose all of your legal rights.

We are reviewing claims from all states in the United States. In addition, we would like to talk to you if you are an American citizen living abroad with a potential claim.

1. Nicolai J, Vles JS, Aldenkamp AP (August 2008). "Neurodevelopmental delay in children exposed to antiepileptic drugs in utero: a critical review directed at structural study-bias". J. Neurol. Sci. 271 (1-2): 1–14. doi:10.1016/j.jns.2008.03.004. PMID 18479711. http://linkinghub.elsevier.com/retrieve/pii/S0022-510X(08)00139-1.

2. Online 'Mendelian Inheritance in Man' (OMIM) 132810

3. Easton JD (December 1972). "Potential hazards of hydantoin use". Ann. Intern. Med. 77 (6): 998–9. PMID 4644176. http://www.annals.org/content/77/6/998.extract.

We thank Wikipedia.org for additional reference materials.

Please call us at 888 446 8087 as soon as possible as delay may cause you to permanently lose your legal rights.

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